FITC标记的阶段特异性胚胎表面抗原-1抗体
产品名称： FITC标记的阶段特异性胚胎表面抗原-1抗体
英文名称： Anti-CD15/FITC
产品编号： HZ-1702R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-CD15/FITC Conjugated antibody
FITC标记的阶段特异性胚胎表面抗原-1抗体
| 英文名称 | Anti-CD15/FITC |
| 中文名称 | FITC标记的阶段特异性胚胎表面抗原-1抗体 |
| 别 名 | Fut4; SSEA-1; 3-FAL; Alpha (1,3) fucosyltransferase; Alpha 13 fucosyltransferase FucT; EC 2.4.1.; ELAM 1 ligand fucosyltransferase; ELAM ligand fucosyltransferase; ELAM1 ligand fucosyltransferase; ELFT; FCT3A; Fuc TIV; Fucosyltransferase 4 alpha 1 3 fucosyltransferase myeloid specific; Fucosyltransferase 4; FucT IV; FUCTIV; FUT4; Galactoside 3 L fucosyltransferase; Lewis X; LeX; SSEA 1; SSEA1; Stage specific embryonic antigen 1; FUC-TIV. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD15 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq]. Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens. Subcellular Location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. Tissue Specificity: Highest expression in stomach and colon. It is also expressed in the lung, testis, uterus, small intestine and to a lesser extent in spleen, and ovary. Present in trace amounts in brain, thymus, heart, smooth muscle, kidney and bone marrow. Not found in liver, salivary gland and pancreas. Similarity: Belongs to the glycosyltransferase 10 family. Database links: Entrez Gene: 10690 Human Entrez Gene: 2526 Human Entrez Gene: 2527 Human Entrez Gene: 2528 Human Entrez Gene: 2529 Human Omim: 104230 Human SwissProt: P22083 Human SwissProt: P51993 Human SwissProt: Q11128 Human SwissProt: Q11130 Human SwissProt: Q9Y231 Human Unigene: 390420 Human Unigene: 457 Human Unigene: 49117 Human Unigene: 572064 Human Unigene: 623098 Human Unigene: 631843 Human Unigene: 631846 Human Unigene: 705615 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD15(SSEA-1)是胚胎干细胞表达胚胎阶段特异性抗原的主要SSEA-1蛋白,还包括、SSEA-3、TRA-1-81、TRA-1-60等。CD15主要存在于粒细胞（包括中性粒细胞和嗜酸性粒细胞）以及部分单核细胞上。它在介导细胞吞噬细菌和趋化性方面起重要作用。CD15常表达于霍奇金氏病中R-S细胞，尤其是经典型霍奇金淋巴瘤中。结节硬化型霍奇金淋巴瘤多为CD15阳性。CD15抗体是鉴定霍奇金氏病的一个有效工具 |
Lewis组织血型系统包括一组由外分泌上皮细胞合成并在体液中循环的岩藻糖化的鞘糖脂。鞘糖脂在胚胎发生、组织分化、肿瘤转移、炎症和细菌粘附中起作用。它们被二次吸收到红细胞中，从而引起其刘易斯表型。该基因是fucosyltransferase家族的成员，它催化岩藻糖在Lewis抗原生物合成的最后一步中添加到前体多糖中。它编码α（1,3）-岩藻糖基转移酶和α（1,4）-岩藻糖基转移酶活性的酶。该基因的突变是大多数Lewis抗原阴性表型的原因。已发现多个交替剪接变异体，编码相同的蛋白质。[由RefSeq提供]。