GCK (Human) Recombinant Protein (Q01)
产品名称： GCK (Human) Recombinant Protein (Q01)
英文名称： GCK (Human) Recombinant Protein (Q01)
产品编号： H00002645-Q01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human GCK partial ORF ( AAH01890.1, 356 a.a. - 465 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- GLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
- Theoretical MW (kDa):
- 37.73
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 2645
- GeneBank Accession#:
- BC001890.1
- Protein Accession#:
- AAH01890.1
- Gene Name:
- GCK
- Gene Alias:
- GK,GLK,HHF3,HK4,HKIV,HXKP,MODY2
- Gene Description:
- glucokinase (hexokinase 4)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq
- Other Designations:
- ATP:D-hexose 6-phosphotransferase,OTTHUMP00000024521,OTTHUMP00000159308,glucokinase,hexokinase D, pancreatic isozyme
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Atherosclerosis
- Birth Weight
- Calcinosis
- Cardiovascular Diseases
- Coronary Artery Disease
- Coronary Disease
- Diabetes Complications
- Diabetes Mellitus
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetes, Gestational
- Diabetic Nephropathies
- Disease Progression
- Disease Susceptibility
- Edema
- Fetal Growth Retardation
- Genetic Predisposition to Disease