FITC标记的G蛋白偶联受体109A抗体
产品名称： FITC标记的G蛋白偶联受体109A抗体
英文名称： Anti-GPR109A/FITC
产品编号： HZ-10079R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-GPR109A/FITC Conjugated antibody
FITC标记的G蛋白偶联受体109A抗体
| 英文名称Anti-GPR109A/FITC中文名称FITC标记的G蛋白偶联受体109A抗体别 名HM74A; G-protein coupled receptor 109A; GPR109A; HM74a; HM74b; NIACR1; Puma-g; PUMAG; Niacr1; Niacin receptor 1; Nicotinic acid receptor; G-protein coupled receptor 109; G-protein coupled receptor HM74; G protein coupled receptor HM74a; G protein coupled receptor Hm74b; Protein PUMA-G; Interferon gamma inducible gene Puma g; Nicotinic acid receptor 1; Nicotinic acid receptor; Puma g; Pumag; rHM74b; HCAR2_HUMAN . 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 研究领域抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, Cow, Rabbit, 产品应用 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量40kDa细胞定位细胞膜 性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human GPR109A/HM74A亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. Function: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 338442 Human Omim: 609163 Human SwissProt: Q8TDS4 Human Unigene: 524812 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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作为烟酸（又称烟酸）和（D）-β-羟基丁酸的高亲和力受体，并通过G（I）介导增加脂联素分泌和减少脂解作用-蛋白介导的腺苷酸环化酶抑制。这种药理作用需要烟酸剂量远远高于正常饮食所提供的烟酸剂量。介导烟酸诱导成熟中性粒细胞凋亡。烟酸的受体激活导致cAMP水平降低，这可能影响cAMP依赖性蛋白激酶A的活性和靶蛋白的磷酸化，从而导致中性粒细胞凋亡。