重组人指(趾)关节粘连NOG蛋白/Recombinant human Noggin protein说明书-分析方法-资讯-生物在线

重组人指(趾)关节粘连NOG蛋白/Recombinant human Noggin protein说明书

作者:上海钰博生物科技有限公司 2023-03-29T00:00 (访问量:199)

 Recombinant human Noggin protein

重组人指(趾)关节粘连NOG蛋白

英文名称 Recombinant human Noggin protein
中文名称 重组人指(趾)关节粘连NOG蛋白
别    名 NOG; SYM 1; SYM1; Symphalangism 1 (proximal); Synostoses (multiple) syndrome 1; SYNS 1; SYNS1; NOGG_HUMAN  
理论分子量 23kDa
性    状 Lyophilized or Liquid
浓    度 >0.5 mg/ml
物    种 Human
序    列 28-232/232
纯    度 > 90% as determined by SDS PAGE
纯化方法 AC
内毒素 Not analyzed
表达系统 HEK293 cell
活性 Not tested
标签 Tag Free
缓 冲 液 PBS (pH=7.4)
保存条件 Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.
 
产品图片
The purity of the protein is greater than 80% as determined by reducing SDS-PAGE.

本产品仅供科研使用.请勿用于医药,不能用于临床治疗诊断使用!

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